Top 6 Malware Persistence Mechanisms Used by Hackers: A Detailed Guide


Persistence mechanisms play a critical role in modern cyberattacks, helping malware remain active on compromised systems even after reboots, log-offs, or restarts.

By exploiting built-in system features, attackers ensure their malicious programs continue operating undetected.

SIEM as a Service

Below, we explore six common persistence techniques used by attackers, as well as how to detect them using tools like ANY.RUN’s Interactive Sandbox, which integrates the MITRE ATT&CK framework to identify malicious activities.

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1. Startup Directory Execution – MITRE ATT&CK ID: T1547.001

Attackers often exploit the Windows Startup directory to achieve persistence. By placing malicious files in this folder, which is designed to automatically execute programs at login, malware ensures it launches every time the system boots up.

Persistence mechanism technique inside ANY.RUN sandbox 
  • Why it works: Most users don’t check their Startup folder, allowing malware to operate unnoticed.
  • Example: The Snake Keylogger malware drops files in the Startup directory, located at:
    C:UsersadminAppDataRoamingMicrosoftWindowsStart MenuProgramsStartup.

Detection Tip: Use ANY.RUN’s sandbox to analyze the Process Tree and identify suspicious file placements in the Startup folder.

2. Registry Autorun Key Modification – MITRE ATT&CK ID: T1547.001

Malware can modify registry keys to ensure automatic execution upon system startup. By altering specific AutoStart Extension Points (ASEPs), attackers embed malware directly into the system’s boot process.

User-level keys targeted:

  • HKEY_CURRENT_USERSoftwareMicrosoftWindowsCurrentVersionRun
  • HKEY_CURRENT_USERSoftwareMicrosoftWindowsCurrentVersionRunOnce

System-level keys targeted (requires admin privileges):

  • HKLMSOFTWAREMicrosoftWindowsCurrentVersionRun
  • HKLMSOFTWAREMicrosoftWindowsCurrentVersionRunOnce
File execution in Startup folder 

Example: This session Njrat malware modifies user-level registry keys for persistence.

Detection Tip: ANY.RUN sandbox highlights registry key changes during analysis.

3. Logon/Logoff Helper Path ModificationMITRE ATT&CK ID: T1547.004

Windows uses registry “helper” paths to execute scripts or programs during user login or logoff. Attackers modify these paths to ensure their malware runs every time a session starts or ends.

Registry path targeted:

HKEY_LOCAL_MACHINESoftwareMicrosoftWindows NTCurrentVersionWinlogon

Detection Tip: Use ANY.RUN to monitor changes to Winlogon registry paths.

4. Kernel Modules and Extensions (Linux)

MITRE ATT&CK ID: T1547.006

Linux systems are vulnerable to persistence mechanisms involving kernel modules. These modules run with root privileges and can be used to embed malicious code directly into the operating system’s core.

Attack process:

  1. Malware gains root access.
  2. A malicious module is loaded using commands like insmod or modprobe.
  3. The module hides its presence by modifying kernel-level functions.
Loading of malicious module detected by ANY.RUN sandbox 

Why it’s stealthy: Standard antivirus tools operate at the user level and can’t detect kernel-level threats.

Detection Tip: Use ANY.RUN to identify malicious module loading activities.

5. Office Application Startup – MITRE ATT&CK ID: T1137

Attackers target Microsoft Office’s startup features to execute malicious code whenever an Office application is launched. Two common methods include:

Macros detected by ANY.RUN sandbox 

Attackers can exploit Microsoft Office by embedding malicious macros in templates or creating harmful add-ins. Malicious templates load automatically whenever the application starts, running harmful code without user interaction.

Similarly, attackers can place malicious add-ins in Office’s add-in directories, ensuring the code activates every time the application is opened. These methods provide persistent access and pose significant security risks.

Example: A macro embedded in a malicious Word document executes each time the file is opened.

Detection Tip: ANY.RUN detects macros and displays malicious Office files inside its virtual machine environment.

6. Boot or Logon Initialization ScriptsMITRE ATT&CK ID: T1037

Attackers modify initialization scripts that run during system boot or user logon to maintain persistence. These scripts, often used for administrative functions, can be altered to execute malware.

  • Example: RC scripts in Linux systems are modified to include malicious code.
  • Why it’s effective: These scripts run automatically, ensuring malware launches without user intervention.

Detection Tip: Monitor changes to boot or logon scripts using ANY.RUN’s analysis tools.

Persistence mechanisms are vital tools for attackers, ensuring malware remains active even after system restarts. From modifying registry keys to embedding malicious kernel modules, these techniques exploit legitimate system features to evade detection.

Tools like ANY.RUN’s Interactive Sandbox provide cybersecurity professionals with powerful capabilities to detect and analyze these persistence methods in real-time. By leveraging the MITRE ATT&CK framework, ANY.RUN simplifies the process of identifying and mitigating threats.

About ANY.RUN

ANY.RUN is a leading platform for interactive malware analysis, used by over 500,000 cybersecurity professionals worldwide. It provides tools like TI Lookup, YARA Search, and Feeds to help users quickly identify Indicators of Compromise (IOCs) and respond effectively to cyber threats.

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